Thu Apr 24 2025
What causes cardiac amyloidosis?
Cardiac amyloidosis is caused primarily by the misfolding of proteins that aggregate to form amyloid deposits. The two main types are light-chain amyloidosis (AL) caused by immunoglobulin light chains produced by abnormal plasma cells, and transthyretin amyloidosis (ATTR) caused by mutations in the transthyretin protein.
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