Is vanishing white matter disease present in adults?

Yes, Vanishing White Matter (VWM) disease can occur in adults, though it is generally recognized as a childhood-onset leukoencephalopathy. Adult cases of VWM often present differently than those in children, with symptoms that may include chronic progressive neurological deterioration, such as ataxia, spasticity, and behavioral changes, alongside fewer severe cognitive declines. Adults may also be less typically diagnosed due to misinterpretation of symptoms or lack of awareness of VWM as a potential diagnosis. Although the classic presentation occurs in childhood, the possibility of adult-onset VWM, particularly with milder neurological deficits, has emerged from clinical observations, emphasizing the necessity for physician awareness and consideration of this rare condition across all age groups.

Leukoencephalopathy with vanishing white matter - Wikipedia