What are the symptoms of hypomyelination?

Hypomyelination results from reduced myelin production, leading to various neurological symptoms depending on the severity and location of demyelination. Common symptoms include developmental delays, motor skill difficulties, diminished coordination and balance (ataxia), sensory deficits, and seizures. Children with hypomyelination may present difficulties in cognitive functioning, behavioral challenges, and visual or auditory processing problems. Symptoms often vary by individual and may worsen or fluctuate depending on physical stress or illness. Imaging techniques like MRI can help visualize white matter anomalies associated with hypomyelination, aiding in diagnosing and managing underlying conditions such as Pelizaeus-Merzbacher disease or VWM disease. It’s essential for affected individuals to receive comprehensive care tailored to their specific symptoms and underlying causes.

Leukoencephalopathy with vanishing white matter - Wikipedia