What treatments are available for vanishing white matter disease?

Currently, there are no specific treatments available for Vanishing White Matter (VWM) disease, and managing the condition focuses primarily on supportive care. This includes strategies to manage symptoms such as seizures, muscle stiffness (spasticity), and difficulties with coordination or motor function. Precautions to minimize trauma, avoid stressors, and prevent infections are recommended. Alongside pharmacological interventions for symptomatic relief, physical therapy can be beneficial to help maintain mobility and function. Melatonin has shown potential for providing cytoprotective benefits in stressed glial cells, which could be relevant in research contexts, although definitive clinical application remains to be established. Ongoing research into pharmacological and genetic therapies aims to enhance understanding and treatment prospects for those affected by VWM.

Leukoencephalopathy with vanishing white matter - Wikipedia